Pomalidomide-5-O-CH3
Pomalidomide-5-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].
Product Specifications
CAS Number
1547163-02-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-5-o-ch3.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=C(C(N)=C2C(N1C3C(NC(CC3)=O)=O)=O)OC
Molecular Formula
C14H13N3O5
Molecular Weight
303.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Frequently Asked Questions
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