Recombinant Human IL1RL1/ST2 Protein

IL-1 receptor– like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

FIT; DER; IL1RL; IL-1 R; IL1RL1; DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1; IL-1 R4; DER-4; FIT 1; Growth stimulation expressed; Growth stimulation expressed gene 2; homolog of mouse growth stimulation-expressed; IL-1R4; ILRL1; Interleukin 1 receptor like 1; interleukin 1 receptor related protein; Interleukin-1 receptor-like 1; Protein ST2; T1 protein

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.