W146 (TFA)
W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
Product Specifications
CAS Number
[909725-62-8]
UNSPSC
12352005
Target
Apoptosis; LPL Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/w146-tfa.html
Concentration
10mM
Purity
98.22
Solubility
DMSO : 20 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O.O=C(O)C(F)(F)F
Molecular Formula
C18H28F3N2O6P
Molecular Weight
456.39
References & Citations
[1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.|[3]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Autophagy. 2025 Apr 10:1-19.|Cancer Commun (Lond) . 2025 Jul 16.|iScience. 2024 Oct 30;27 (12) :111290.|J Nutr Biochem. 2024 Apr:126:109587.|Nat Cell Biol. 2025 Jun;27 (6) :918-930.
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