FXR agonist 7

FXR agonist 7 (compound 33) is a potent agonist of FXR, with EC50 of 0.1 nM. FXR agonist 7 shows high intestinal distribution, good anti-inflammatory activity[1].

Product Specifications

UNSPSC

12352005

Target

FXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fxr-agonist-7.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN(C2=C1C=CC(N3CCC4(CC3)CC(C4)COCC5=C(ON=C5C6=CC=CC=C6OC(F)(F)F)C7CC7)=C2)CC)O

Molecular Formula

C34H36F3N3O5

Molecular Weight

623.66

References & Citations

[1]Yuan Li, et al. Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2024 Apr 11;67 (7) :5642-5661.