VRT-532

VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].

Product Specifications

CAS Number

[38214-71-0]

Product Name Alternative

CFpot-532

UNSPSC

12352005

Hazard Statement

H302, H318

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vrt-532.html

Purity

98.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C=CC(C)=C1)=C1C2=NNC(C3=CC=CC=C3)=C2

Molecular Formula

C16H14N2O

Molecular Weight

250.30

Precautions

H302, H318

References & Citations

[1]Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418 (1) :185-90. |[2]Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR) -processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282 (46) :33247-33251.