TBCA
Product Specifications
UNSPSC Description
TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].
Target Antigen
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tbca.html
Purity
99.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(/C=C/C1=C(C(Br)=C(Br)C(Br)=C1)Br)=O
Molecular Weight
463.74
References & Citations
[1]Pagano MA, et al. Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007;8(1):129-139.|[2]Ryu SY, Kim S. Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet function. Eur J Pharmacol. 2013;720(1-3):391-400.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110052/TBCA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110052/TBCA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
934358-00-6
Available Sizes
Curated Selection
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