ZINC13466751
ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 µM[1].
Product Specifications
CAS Number
[117953-17-0]
UNSPSC
12352005
Hazard Statement
H302, H318
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/zinc13466751.html
Purity
99.94
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(C1=CC=CC=C1)N=C/2C)C2=N/NC3=CC=C(N4CCOCC4)C=C3
Molecular Formula
C20H21N5O2
Molecular Weight
363.41
Precautions
H302, H318
References & Citations
[1]Xue X, et al. Discovery of novel inhibitors disrupting HIF-1α/von Hippel-Lindau interaction through shape-based screening and cascade docking. PeerJ. 2016 Dec 15;4:e2757.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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