Recombinant Human FLT3 Protein (GST Tag, Active)

<strong>Recombinant Human FLT3 Protein (GST Tag, Active)</strong>_x000D_ <strong>Catalog number:</strong> B2018993_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> ~73 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> CD135 Protein, Human; FLK-2 Protein, Human; FLK2 Protein, Human; STK1 Protein, Human_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Padella A, Ghelli Luserna Di Rorà A, Marconi G, Ghetti M, Martinelli G, Simonetti G. Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies J Hematol Oncol. 2022 Jan 22;15(1):10._x000D_ 2: Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype N Engl J Med. 2005 Jan 20;352(3):254-66._x000D_ 3: Ly BTK, Chi HT. ETV6/FLT3 Fusion Is a Novel Client Protein of Hsp90 Oncol Res. 2018 Sep 14;26(8):1201-1205._x000D_ 4: Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group Blood. 2017 Jun 22;129(25):3352-3361._x000D_ 5: Zhang D, Guo Y, Zhao Y, Yu L, Chang Z, Pei H, Huang J, Chen C, Xue H, Xu X, Pan Y, Li N, Zhu C, Zhao ZJ, Yu J, Chen Y. Expression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression Microb Cell Fact. 2021 Mar 10;20(1):67._x000D_ 6: Verstraete K, Koch S, Ertugrul S, Vandenberghe I, Aerts M, Vandriessche G, Thiede C, Savvides SN. Efficient production of bioactive recombinant human Flt3 ligand in E. coli Protein J. 2009 Feb;28(2):57-65._x000D_ 7: Xu Z, Xu Y, Zhu J, Shi Q, Li Y, Zhang X. Recombinant human Flt3 ligand exerts both direct and indirect effects on hematopoiesis Chin Med J (Engl). 2002 Feb;115(2):202-5._x000D_ 8: Arora D, Stopp S, Böhmer SA, Schons J, Godfrey R, Masson K, Razumovskaya E, Rönnstrand L, Tänzer S, Bauer R, Böhmer FD, Müller JP. Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling J Biol Chem. 2011 Apr 1;286(13):10918-29._x000D_ 9: Vekariya U, Toma M, Nieborowska-Skorska M, Le BV, Caron MC, Kukuyan AM, Sullivan-Reed K, Podszywalow-Bartnicka P, Chitrala KN, Atkins J, Drzewiecka M, Feng W, Chan J, Chatla S, Golovine K, Jelinek J, Sliwinski T, Ghosh J, Matlawska-Wasowska K, Chandramouly G, Nejati R, Wasik M, Sykes SM, Piwocka K, Hadzijusufovic E, Valent P, Pomerantz RT, Morton G, Childers W, Zhao H, Paietta EM, Levine RL, Tallman MS, Fernandez HF, Litzow MR, Gupta GP, Masson JY, Skorski T. DNA polymerase θ protects leukemia cells from metabolically induced DNA damage Blood. 2023 May 11;141(19):2372-2389._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/15583855">10: Naoe T, Kiyoi H. Normal and oncogenic FLT3 Cell Mol Life Sci. 2004 Dec;61(23):2932-8. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human FLT3 Protein (GST Tag, Active) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>