N, N-Dimethylacetamide

N, N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease[1][2][3].

Product Specifications

CAS Number

[127-19-5]

Product Name Alternative

DMAc

UNSPSC

12352200

Hazard Statement

H227, H312+H332, H319, H360

Target

NF-κB

Type

Biochemical Assay Reagents

Related Pathways

NF-κB

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/N,N-Dimethylacetamide.html

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(N(C)C)=O

Molecular Formula

C4H9NO

Molecular Weight

87.12

Precautions

H227, H312+H332, H319, H360

References & Citations

[1]Sundaram S, et al. N, N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth. Am J Pathol. 2013 Aug;183 (2) :422-30.|[2]Wei ZH, et al. N, N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models. Sci Rep. 2023 May 1;13 (1) :7077.|[3]Koya JB, et al. FDA-Approved Excipient N, N-Dimethylacetamide Attenuates Inflammatory Bowel Disease in In Vitro and In Vivo Models. Fortune J Health Sci. 2022;5:499-509.