WAY-181187
WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
Product Specifications
CAS Number
[554403-49-5]
Product Name Alternative
SAX-187
UNSPSC
12352005
Target
5-HT Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/way-181187.html
Purity
98.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4
Molecular Formula
C15H13ClN4O2S2
Molecular Weight
380.87
References & Citations
[1]Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33 (6) :1323-35.|[2]Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661 (1-3) :8-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Peptides
Clinical Information
Phase 1
Isoform
5-HT6 Receptor; MUC2
Available Sizes
Curated Selection
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