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Cabozantinib

Product Specifications

CAS Number

849217-68-1

Target

C-Kit, TAM Receptor, VEGFR, Apoptosis, c-RET, FLT, c-Met/HGFR

Related Pathways

Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis

Purity

0.9988

Bioactivity

Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM) . Cabozantinib exhibits both antitumor and antiangiogenic activity.

Smiles

C(NC1=CC=C(OC=2C3=C(C=C(OC)C(OC)=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4

Molecular Formula

C28H24FN3O5

Molecular Weight

501.51

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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