Cabozantinib
Product Specifications
CAS Number
849217-68-1
Target
C-Kit, TAM Receptor, VEGFR, Apoptosis, c-RET, FLT, c-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis
Purity
0.9988
Bioactivity
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM) . Cabozantinib exhibits both antitumor and antiangiogenic activity.
Smiles
C(NC1=CC=C(OC=2C3=C(C=C(OC)C(OC)=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4
Molecular Formula
C28H24FN3O5
Molecular Weight
501.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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