CAIX Antibody / Carbonic Anhydrase IX
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. Carbonic anhydrase IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. [RefSeq]
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
Q16790
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the CAIX antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
CBAD9-1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the CAIX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CAIX antibody is available for research use only.
Storage Conditions
Store the CAIX antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell surface and cytoplasmic
Image Legend
IHC testing of FFPE human renal cell carcinoma with CAIX antibody (clone CBAD9-1) .
Frequently Asked Questions
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