SQA1
SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intracellular pocket occupied by SQA1 overlaps with the G protein binding site and stabilizes the closed conformation of the intracellular pocket[1].
Product Specifications
CAS Number
1255915-27-5
UNSPSC
12352005
Target
CCR; CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sqa1.html
Smiles
OC1=C(NC2=C(N[C@H](CC)C3=CC(C(C)C)=CO3)C(C2=O)=O)C=CN=C1C(N(C)C)=O
Molecular Formula
C22H26N4O5
Molecular Weight
426.47
References & Citations
[1]David Jonathan Wasilko, et al. Structural basis for CCR6 modulation by allosteric antagonists. bioRxiv. April 06, 2024
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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