Tolmetin

Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) [1][2].

Product Specifications

CAS Number

[26171-23-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tolmetin.html

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CC1=CC=C(C(C2=CC=C(C)C=C2)=O)N1C

Molecular Formula

C15H15NO3

Molecular Weight

257.28

Precautions

H302, H315, H319, H335

References & Citations

[1]T D Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999 Jun 22;96 (13) :7563-8.|[2]DADAŞ, Yakup, et al. Synthesis and anticancer activity of some novel tolmetin thiosemicarbazides. Marmara Pharmaceutical Journal 19 (3) • April 2015|[3]Etcheverry SB, et al. Three new vanadyl (IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) . Bioactivity on osteoblast-like cells in culture. J Inorg Biochem. 2002 Jan 1;88 (1) :94-100.