2',3'-Cyclic NADP (disodium)

2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.

Product Specifications

CAS Number

[100929-77-9]

Product Name Alternative

2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate

UNSPSC

12352005

Target

Calcium Channel; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-3-cyclic-nadp-disodium.html

Purity

Smiles

O=[P](O[P](OC[C@H]([C@H]1O)O[C@]([N+]2=CC=CC(C(N)=O)=C2)([H])[C@@H]1O)([O-])=O)(O[Na])OC[C@H]3O[C@](N4C5=NC=NC(N)=C5N=C4)([H])[C@@](O6)([H])[C@]3([H])O[P]6(O[Na])=O