PTPN11 antibody

PTPN11 (protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism (PMID:19017799) . Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions (PMID:21576358) . Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1), Noonan syndrome type 1 (NS1), juvenile myelomonocytic leukemia (JMML) and metachondromatosis (MC) . It has 3 isoforms produced by alternative splicing.

Tyrosine-protein phosphatase non-receptor type 11|Protein-tyrosine phosphatase 1D (PTP-1D) |Protein-tyrosine phosphatase 2C (PTP-2C) |SH-PTP2 (SHP-2, Shp2) |SH-PTP3|PTPN11|PTP2C|SHPTP2