JTC-801
JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2 nM.
Product Specifications
CAS Number
244218-51-7
UNSPSC
12352005
Hazard Statement
H319, H413
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JTC-801.html
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 0.33 mg/mL
Smiles
NC1=CC(C)=NC2=C1C=C(NC(C3=C(COC4=CC=C(C=C4)CC)C=CC=C3)=O)C=C2.[H]Cl
Molecular Formula
C26H26ClN3O2
Molecular Weight
447.96
Precautions
H319, H413
References & Citations
[1]Yamada H, et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL (1) ) receptor antagonist, JTC-801. Br J Pharmacol, 2002, 135 (2), 323-332.|[2]Shinkai H, et al. 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J Med Chem, 2000, 43 (24), 4667-4677.|[3]Zhang Y, et al. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan;172 (2) :571-82.|[4]Koyama T, et al. Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23 (2) :301-3.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NOP Receptor/ORL1
Available Sizes
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