PRLX-93936 (dihydrochloride)

PRLX-93936 dihydrochloride (Compound 16) is a HIF-1α inhibitor with anticancer activity. PRLX-93936 can inhibit the activated Ras pathway and can be used in the study of relapsed or refractory multiple myeloma[1][2].

Product Specifications

CAS Number

[1094210-96-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

HIF/HIF Prolyl-Hydroxylase; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prlx-93936-dihydrochloride.html

Purity

99.83

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C(CN2CCNCC2)=NC3=C1C=CC=C3)C4=CC=CC=C4OCC.Cl.Cl

Molecular Formula

C21H26Cl2N4O2

Molecular Weight

437.36

Precautions

H302, H315, H319

References & Citations

[1]Huang W, et al. Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorg Med Chem Lett. 2011 Sep 15;21 (18) :5239-43.|[2]Voorhees P M, et al. An open-label, dose escalation, multi-center phase 1 study of PRLX 93936, an agent synthetically active against the activated ras pathway, in the treatment of relapsed or relapsed and refractory multiple myeloma[J]. Blood, 2014, 124 (21) : 2140.