KGP-25

KGP-25 is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8), which can be used for analgesia by targeting Nav1.8 in the peripheral nervous system (PNS) . KGP-25 can also target γ-aminobutyric acid subtype A receptor (GABAA) in the central nervous system (CNS) for general anesthesia[1].

Product Specifications

UNSPSC

12352005

Target

GABA Receptor; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kgp-25.html

Purity

95.0

Smiles

CC(C1=C(C(C(C)C)=CC=C1)OC(OCC[NH+](CC)CC)=O)C.[Cl-]

Molecular Formula

C19H32ClNO3

Molecular Weight

357.92

References & Citations

[1]Huang T, ey al. Molecular Transformers: Adaptive Multitarget Ligands for Esterase-Induced Transition from Analgesics to Anesthetics. J Med Chem. 2024 Jul 25;67 (14) :12349-12365.