VEGFR3 monoclonal antibody
Product Specifications
Background
Vascular endothelial growth factor receptor 3 (VEGFR3) is a 195 kDa membrane receptor tyrosine kinase. VEGF receptors are characterized by the presence of seven extracellular immunoglobulin (Ig) -like domains followed by a membrane-spanning domain and a conserved intracellular tyrosine kinase domain . VEGF receptor 3 expression is largely restricted to adult lymphatic endothelium and is thought to control lymphangiogenesis . Binding of VEGF-C/VEGF-D to VEGFR3 results in transphosphorylation of tyrosine residues in its intracellular domain, recruitment of signaling molecules and activation of ERK1/2 and Akt signaling cascades .
CAS Number
9007-83-4
Structure Composition
Mouse IgG2a. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
VEGFR3; Vascular endothelial growth factor receptor 3; VEGFR-3; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
Swiss Prot
P35916
Reactivity
Human
Immunogen
Recombinant fusion protein of human VEGFR3. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, FC
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 175 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of VEGFR3 protein.
Applications Notes
Western blot analysis of VEGFR3 expression in A549 (A), 293T (B) whole cell lysates.
Host or Source
Mouse
Available Sizes
Frequently Asked Questions
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