SIRT5 inhibitor 6
SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo[1].
Product Specifications
CAS Number
[2834736-82-0]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sirt5-inhibitor-6.html
Solubility
10 mM in DMSO
Smiles
S=C(NCCCNC1=NC(NCC2=CC=CC=C2)=NC=C1C(OCC)=O)NCCC(O)=O
Molecular Formula
C21H28N6O4S
Molecular Weight
460.55
References & Citations
[1]Luohe Mou, et al, Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66 (16) :11517-11535.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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