HSP90-IN-14
HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively[1].
Product Specifications
CAS Number
[1995132-67-6]
UNSPSC
12352005
Target
HSP; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hsp90-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(NC1=CC=C2N=C(NC(C3=CC(Cl)=C(Cl)N3)=O)SC2=C1)=O
Molecular Formula
C14H8Cl2N4O4S
Molecular Weight
399.21
References & Citations
[1]Lamut A, et al. Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90. Bioorg Chem. 2020 May;98:103733.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
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