Recombinant Mouse IFNAR1 Protein (His Tag)

Product Specifications

Background

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2 . Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha-and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

Abbreviation

IFNAR1

Synonyms

CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN-R-1 IFN-alpha/beta receptor 1; IFNAR; Interferon alpha/beta receptor 1; Type I interferon receptor 1

UniProt

P33896

Accession Number

P33896-1

Expression System

E.coli

Tag

N-His

Sequence

Glu27-Cyc284

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 85% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.