Keap1-Nrf2-IN-10
Product Specifications
UNSPSC Description
Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice[1].
Target Antigen
Reactive Oxygen Species
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-10.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(NC(CSC2=NC3=C(C=C(C=C3C(N2C4=CC=C(C=C4)S(N)(=O)=O)=O)I)I)=O)=CC(OC)=C1OC
Molecular Weight
808.40
References & Citations
[1]Soliman AM, et al. Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety. Eur J Med Chem. 2020 Aug 15;200:112467.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147548/Keap1-Nrf2-IN-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147548/
Clinical Information
No Development Reported
CAS Number
2445349-54-0
Curated Selection
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