BTK inhibitor 17

BTK inhibitor 17 is a potent and orally active irreversible BTK inhibitor with an IC50 of 2.1 nM. BTK inhibitor 17 can be used for rheumatoid arthritis research[1].

Product Specifications

CAS Number

[1858206-76-4]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/btk-inhibitor-17.html

Purity

99.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(N([C@H]2CN(C(C=C)=O)CCC2)N=C3C4=CC=C(OC5=CC=CC=C5)C=C4)=C3C(N)=NN1

Molecular Formula

C25H24N6O3

Molecular Weight

456.50

References & Citations

[1]Xuejun Zhang, et al. Discovery and Evaluation of Pyrazolo[3,4- d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor. ACS Med Chem Lett. 2019 Dec 11;11 (10) :1863-1868.