GK563
GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes[1].
Product Specifications
CAS Number
2351820-19-2
UNSPSC
12352005
Target
Apoptosis; Phospholipase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gk563.html
Solubility
10 mM in DMSO
Smiles
CCC[C@H]1[C@@H](C(O1)=O)CCCCC2=CC=CC=C2
Molecular Formula
C16H22O2
Molecular Weight
246.34
References & Citations
[1]Dedaki C, et al. β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis. J Med Chem. 2019 Mar 28;62 (6) :2916-2927.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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