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Zimelidine

Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant[1][2][3][4].

Product Specifications

CAS Number

56775-88-3

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

5-HT Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zimelidine.html

Solubility

10 mM in DMSO

Smiles

CN(C/C=C(C1=CC=CN=C1)/C2=CC=C(C=C2)Br)C

Molecular Formula

C16H17BrN2

Molecular Weight

317.22

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Heel RC, et al. Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1982 Sep;24 (3) :169-206.|[2]Blier P, et al. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci. 1983 Jun;3 (6) :1270-8.|[3]Ozdemir E, et al. Zimelidine attenuates the development of tolerance to morphine-induced antinociception. Indian J Pharmacol. 2012 Mar;44 (2) :215-8.|[4]Scopinho AA, et al. Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats. Neuropharmacology. 2012 Aug;63 (2) :301-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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