6-Oxolithocholic acid

6-Oxolithocholic acid is a bile acid metabolite derived from Lithocholic acid (HY-B0172) . 6-Oxolithocholic acid has high cytotoxicity and can induce apoptosis, especially in hepatocytes. 6-Oxolithocholic acid can participate in the regulation of bile acid metabolism and synthesis and affect the metabolic pathway of cholesterol. 6-Oxolithocholic acid can be used to study the role of bile acids in health and disease, especially in the context of digestive and liver diseases[1].

Product Specifications

CAS Number

[2393-61-5]

Product Name Alternative

6-Ketolithocholic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/6-oxolithocholic-acid.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](CC([C@]1([H])C[C@@H](CC2)O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(O)=O)C

Molecular Formula

C24H38O4

Molecular Weight

390.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Zimniak P, et al. Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes[J]. Journal of lipid research, 1989, 30 (6) : 907-918.