SLC7A11-IN-2

SLC7A11-IN-2 (Compound 1) is an SLC7A11/xCT inhibitor. SLC7A11-IN-2 induces cell death in HeLa cells by lowering intracellular glutathione levels and increasing oxidative stress, thereby disrupting the oxidative balance within the cells, with an IC50 value of 10.23 μM. Molecular dynamics simulation analysis indicates that SLC7A11-IN-2 has a stronger binding affinity to SLC7A11 compared to Erastin (HY-15763) . SLC7A11-IN-2 can be utilized in research within the field of cervical cancer[1].

Product Specifications

CAS Number

[14668-59-8]

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/slc7a11-in-2.html

Purity

99.80

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=C(C(CC(CC)O)C(NNC1=CC=CC=C1)=O)NNC2=CC=CC=C2

Molecular Formula

C19H24N4O3

Molecular Weight

356.42

References & Citations

[1]Yue J, et al. Discovery of the Inhibitor Targeting the SLC7A11/xCT Axis through In Silico and In Vitro Experiments. Int J Mol Sci. 2024 Jul 29;25 (15) :8284.