ZK 216348
Product Specifications
Product Name Alternative
(+)-ZK 216348
UNSPSC Description
ZK 216348 ((+)-ZK 216348) is a nonsteroidal selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC50s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects[1][2].
Target Antigen
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zk-216348.html
Purity
98.59
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=C(C=C2C(C)=NO1)NC(C(C(F)(F)F)(O)CC(C)(C3=C4C(CCO4)=CC=C3)C)=O
Molecular Weight
476.45
References & Citations
[1]Schäcke H, et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):227-32.|[2] Reuter KC, et al. Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis. J Pharmacol Exp Ther. 2012 Apr;341(1):68-80.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123352/ZK-216348-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123352/ZK-216348-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
669073-68-1
Available Sizes
Curated Selection
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