PSMA-azide
PSMA-azide is a prostate-specific membrane antigen (PSMA) ligand. PSMA-azide inhibits PSMA-dependent NAAG (N-acetylaspartylglutamic acid) hydrolysis, with an IC50 of 9 nM and a Ki of 1 nM. PSMA-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups[1].
Product Specifications
CAS Number
[2374814-84-1]
UNSPSC
12352203
Target
PSMA
Type
ADC Related
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/psma-val-cit-pab-azide.html
Purity
99.43
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(NCCCN=[N+]=[N-])=O)CC(C=C1)=CC=C1O)[C@@H](NC(CCC(NCCCCCC(N(CCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)CC2=CC(Cl)=CC=C2)=O)=O)=O)CC3=CC=CC=C3
Molecular Formula
C50H65ClN10O13
Molecular Weight
1049.56
References & Citations
[1]Machulkin AE, et al. Synthesis and Biological Evaluation of PSMA Ligands with Aromatic Residues and Fluorescent Conjugates Based on Them. J Med Chem. 2021 Apr 22;64 (8) :4532-4552.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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