Human CTLA4 Protein

<strong>Human CTLA4 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2012069_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CTLA-4, CTLA-4 protein, CTLA 4, GSE protein, GRD4 protein, CELIAC3 protein, CTLA4, ICOS protein, IDDM12 protein, CD152 protein, Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor protein, CTLA 4 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Rowshanravan B, Halliday N, Sansom DM. CTLA-4: a moving target in immunotherapy Blood. 2018 Jan 4;131(1):58-67._x000D_ 2: Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited Annu Rev Immunol. 2005;23:515-48._x000D_ 3: Byun DJ, Wolchok JD, Rosenberg LM, Girotra M. Cancer immunotherapy - immune checkpoint blockade and associated endocrinopathies Nat Rev Endocrinol. 2017 Apr;13(4):195-207._x000D_ 4: Chen J, Yang J, Li H, Yang Z, Zhang X, Li X, Wang J, Zhang Y, Chen S, Song M. Single-cell transcriptomics reveal the intratumoral landscape of infiltrated T-cell subpopulations in oral squamous cell carcinoma Mol Oncol. 2021 Apr;15(4):866-886._x000D_ 5: Lee HT, Lee SH, Heo YS. Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology Molecules. 2019 Mar 26;24(6):1190._x000D_ 6: Chang HW, Frey G, Liu H, Xing C, Steinman L, Boyle WJ, Short JM. Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2020606118._x000D_ 7: Tremelimumab Drugs R D. 2010;10(2):123-32._x000D_ 8: Mantia CM, Buchbinder EI. Immunotherapy Toxicity Hematol Oncol Clin North Am. 2019 Apr;33(2):275-290._x000D_ 9: Fife BT, Bluestone JA. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways Immunol Rev. 2008 Aug;224:166-82._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/16227604">10: Parry RV, Chemnitz JM, Frauwirth KA, Lanfranco AR, Braunstein I, Kobayashi SV, Linsley PS, Thompson CB, Riley JL. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms Mol Cell Biol. 2005 Nov;25(21):9543-53. </a>_x000D_ _x000D_ <strong>Products Related to Human CTLA4 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>