Juglone
Product Specifications
UNSPSC Description
Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity
[1][2][3].
Target Antigen
Apoptosis; Bacterial; NF-κB; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis;Immunology/Inflammation;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/juglone.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)|Ethanol : 10 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=C1O)C=CC2=O
Molecular Weight
174.155
References & Citations
[1]Zmantar T, et al. Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity. Microb Pathog. 2016 Dec;101:44-49.|[2]Ji YB, et al. Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp Toxicol Pathol. 2011 Jan;63(1-2):69-78.|[3]Peng X, et al. Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats. Biochem Biophys Res Commun. 2015 Jul 3;462(3):245-50.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6949/Juglone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6949/Juglone-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
481-39-0
Available Sizes
Curated Selection
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