PROTAC K-Ras Degrader-4
PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway[1]. (Pink: ligand for target protein pan-KRAS degrader 1 (HY-162960) ; Black: linker (HY-159790) ; Blue: ligand for E3 ligase VHL (HY-W998248) )
Product Specifications
CAS Number
[2938169-99-2]
UNSPSC
12352005
Target
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-k-ras-degrader-4.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C50H60N12O6S2
Molecular Weight
989.22
References & Citations
[1]Popow J, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024 Sep 20;385 (6715) :1338-1347.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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