IRAK-M rabbit pAb
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
Product Specifications
Background
Product Name Alternative
IRAK3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M
UniProt
Q9Y616
Swiss Prot
Q9Y616
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human IRAK3. AA range:491-540
Target
IRAK-M
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Buffer
-20°C/1 year
Molecular Weight
68kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
68kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . In dendritic cells, translocates into the nucleus upon IL33 stimulation. .
Other Product Names
IRAK3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M
Gene ID (Human)
11213
Available Sizes
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