PLX-51107

PLX-51107 is a potent inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon administration, PLX51107 binds to the acetylated lysine recognition motifs in the bromodomains of the BRD4 protein, thereby preventing the binding of BRD4 to acetylated lysines on histones. This disrupts chromatin remodeling and gene expression.