Licochalcone E

Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation[1].

Product Specifications

CAS Number

[864232-34-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Autophagy; p38 MAPK

Type

Natural Products

Related Pathways

Autophagy; MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/licochalcone-e.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(O)C=C1)/C=C/C2=CC([C@@H](C)C(C)=C)=C(O)C=C2OC

Molecular Formula

C21H22O4

Molecular Weight

338.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee HN, et al. Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. Int J Mol Sci. 2013 May 24;14 (6) :10926-43.