GSK3186899
Product Specifications
UNSPSC Description
GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12), with an EC50 of 1.4 μM for L. donovani in an intra-macrophage assay.
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK3186899.html
Purity
98.61
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(CCC(F)(F)F)(N[C@H]1CC[C@H](NC2=NC=C3C(NN=C3N4C[C@H](C)OCC4)=N2)CC1)=O
Molecular Weight
491.53
References & Citations
[1]Wyllie S, et al. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. Nature. 2018 Aug;560(7717):192-197.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112622/GSK3186899-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112622/GSK3186899-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1972617-87-0
Available Sizes
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