GSK3186899

GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12), with an EC50 of 1.4 μM for L. donovani in an intra-macrophage assay.

Product Specifications

CAS Number

[1972617-87-0]

Product Name Alternative

DDD-853651

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK3186899.html

Concentration

10mM

Purity

98.96

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(CCC(F)(F)F)(N[C@H]1CC[C@H](NC2=NC=C3C(NN=C3N4C[C@H](C)OCC4)=N2)CC1)=O

Molecular Formula

C19H28F3N7O3S

Molecular Weight

491.53

References & Citations

[1]Wyllie S, et al. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. Nature. 2018 Aug;560 (7717) :192-197.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Leishmania

Available Sizes

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