ML334

ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].

Product Specifications

CAS Number

[1432500-66-7]

Product Name Alternative

LH601A

UNSPSC

12352005

Target

Keap1-Nrf2; Quinone Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ml334.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 44.65 mg/mL (ultrasonic) |Ethanol : 44.65 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1C2=O)N2C[C@@H]3C4=CC=CC=C4CCN3C([C@H]5[C@H](CCCC5)C(O)=O)=O

Molecular Formula

C26H26N2O5

Molecular Weight

446.50

References & Citations

[1]Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29 (6) :261-6.|[2]Hu L, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett. 2013 May 15;23 (10) :3039-43.