IACS-8968
Product Specifications
UNSPSC Description
IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.
Target Antigen
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IDO/TDO_Inhibitor.html
Purity
98.46
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1)NC2(C(C)(C)CN(C3=CC(C(F)(F)F)=CC4=CN=CN34)CC2)C1=O
Molecular Weight
381.35
References & Citations
[1]ARYL SULFONOHYDRAZIDES. WO 2017189386 A1|[2]Hamilton MM, Mseeh F, McAfoos TJ, et al. Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme. J Med Chem. 2021;64(15):11302-11329.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112164/IACS-8968-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112164/IACS-8968-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2144425-14-7
Available Sizes
Curated Selection
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