IACS-8968

IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

Product Specifications

CAS Number

[2144425-14-7]

Product Name Alternative

IDO/TDO Inhibitor

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IDO/TDO_Inhibitor.html

Purity

98.46

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1)NC2(C(C)(C)CN(C3=CC(C(F)(F)F)=CC4=CN=CN34)CC2)C1=O

Molecular Formula

C17H18F3N5O2

Molecular Weight

381.35

References & Citations

[1]ARYL SULFONOHYDRAZIDES. WO 2017189386 A1|[2]Hamilton MM, Mseeh F, McAfoos TJ, et al. Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme. J Med Chem. 2021;64 (15) :11302-11329.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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