Ganetespib
Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1α and STAT3[1][2][3][4][5][6].
Product Specifications
CAS Number
[888216-25-9]
Product Name Alternative
STA-9090
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ganetespib.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CN1C2=CC=C(N3C(NN=C3C4=CC(C(C)C)=C(O)C=C4O)=O)C=C2C=C1
Molecular Formula
C20H20N4O3
Molecular Weight
364.40
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15205/Ganetespib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15205/Ganetespib-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
HSP90
Available Sizes
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