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PH-064

Product Specifications

CAS Number

892546-37-1

Synonyms

BIM-46187

Target

GPR

Applications

GPCR & G Protein

Smiles

NC (CSSCC (N) C (=O) N1CC[N]2C=C (N=C2C1CC3CCCCC3) C4=CC=CC=C4) C (=O) N5CC[N]6C=C (N=C6C5CC7CCCCC7) C8=CC=CC=C8

Molecular Formula

C44H58N8O2S2

Additionnal Information

PH-064 (BIM-46187) is a novel imidazo-pyrazine derivative that inhibits the heterotrimeric G-protein complex effectively. PH-064 (BIM46174) inhibits heterotrimeric G-protein signalling in GPCRsthat mediate cyclic AMP generation (GAs), calcium release (GAq), cancer cell invasion by Wnt-2 frizzled receptors, and high-affinity neurotensin receptors (GAo/i and GAq) .

Storage Conditions

3 years -20°C powder

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