DCPIB
Product Specifications
CAS Number
82749-70-0
Target
Potassium Channel
Applications
Transmembrane Transporters
Smiles
CCCCC1 (CC2=CC (=C (Cl) C (=C2C1=O) Cl) OCCCC (O) =O) C3CCCC3
Molecular Formula
C22H28Cl2O4
Additionnal Information
DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC) . DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. DCPIB is also a novel selective blocker of I (Cl, swell), which blocks native I (Cl, swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC (50) of 4.1 μM.
Storage Conditions
3 years -20°C powder
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