CM272
Product Specifications
CAS Number
1846570-31-7
Target
DNA Methyltransferase
Applications
Epigenetics
Smiles
CC1=CC=C (O1) C2=NC3=CC (=C (C=C3C (=C2) NC4CCN (CC4) C) OC) OCCCN5CCCC5
Molecular Formula
C28H38N4O3
Additionnal Information
CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death.
Storage Conditions
3 years -20°C powder
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