EB1
Product Specifications
UNSPSC Description
EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2].
Target Antigen
Apoptosis; Eukaryotic Initiation Factor (eIF); MNK
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eb1.html
Solubility
DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
NC1=NNC2=C1C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2
Molecular Weight
286.33
References & Citations
[1]Bou-Petit E, et al. Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor. J Med Chem. 2022 Apr 28;65(8):6070-6087. |[2]Aboukhatwa SM, et al. Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition. Bioorg Chem. 2022 Dec;129:106126.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146805/EB1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146805/EB1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
42951-68-8
Available Sizes
Curated Selection
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