BSH-IN-1
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively[1].
Product Specifications
CAS Number
[2553217-91-5]
UNSPSC
12352211
Hazard Statement
H302, H314
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bsh-in-1.html
Purity
99.82
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(CF)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Formula
C25H41FO3
Molecular Weight
408.59
Precautions
H302, H314
References & Citations
[1]Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases.Nat Chem Biol. 2020 Mar;16 (3) :318-326.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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