Hamartin Rabbit monoclonal antibody
Product Specifications
Background
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Hamartin; kiaa0243; LAM; TSC; Tsc1; Tuberous sclerosis 1
Swiss Prot
Q92574
Reactivity
Human
Immunogen
A synthesized peptide derived from human Hamartin
Conjugation
Unconjugated
Applications
WB IHC ICC/IF FC
Dilution
WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:200
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
150kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Hamartin Antibody detects endogenous levels of total Hamartin
Applications Notes
Western blot analysis of Hamartin expression in HeLa cell lysate.
Host or Source
Rabbit
Available Sizes
Curated Selection
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